LYCOPENE HEPATOPROTECTIVE PDF

Bisphenol A (BPA)—an endocrine disruptor xenoestrogen—is widely spread in the environment. Lycopene (LYC) is an antioxidant. Background: The exact role of lycopene has not been studied in the past for its hepatoprotective effects. Hence it was decided to explore its anti-oxidant and. In this experimental approach we have established measurements of the hepatoprotective efficiency of lycopene using oxidative stress markers in both.

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Ly displays a range of unique and distinct biological properties owing to its acyclic structure, hydrophobicity and large array of conjugated double bonds. Finally, the 4th group was administrated both BPA and LYC at the same doses of the 2nd and 3rd groups daily via gavage.

All these effects downregulated hepatic caspase-3, thus reducing apoptosis and thus keeping hepatic integrity, and prevented the liberation of hepatic enzymes into the blood of female Wistar rats. Single-cell suspensions were prepared from frozen livers according to the method described by Smith et al. At the end of the experiment, female rats at luteal phase of estrous cycle diestrus were anesthetized via diethyl ether inhalation. Lycopenee is defined by hepatic fat deposition in the absence of excessive alcohol intake, which is also associated with the insulin resistance IR and metabolic syndrome[ 18 – 20 ].

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A significant decrease was observed in the levels of serum AST 2.

Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat

Due to the wide spreading of the usage of BPA in manufacture, both animals and human are daily exposed to BPA hazardous effects [ 6 ]. Sixty-five rats were randomly divided into normal group, model group and Ly treatment groups. Rats supplemented with LYC only did not differ from the control group Table 2. Please review our privacy policy.

The exact role of lycopene has not been studied in the past for its hepatoprotective effects. Lipid profile calorimetric kits were purchased from Diamond diagnostic Co.

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Lycopene modulates nitric oxide pathways against 3-nitropropionic acid-induced neurotoxicity. Body and Liver Weights Rats were weighed at the beginning of the experiment and then weighed at the end of the experiment. ,ycopene finding harmonized with Sheriff and Devaki [ 54 ] and Jiang et al. Amina El Dessouki, Department of Pathology, for giving histopathology comments. All treatments continued for 30 days.

Hepatoprotective Effect of Olive and Argan Oils Supplemented with Tomato Lycopene in Wistar Rats

Rats were given ad libitum diet and drinking water. The 1st group received corn oil and considered as a control. It can immigrate into food or water on heating [ 5 ]. Gastroenterology and hepatology Country of origin: Indexed in Science Citation Index Expanded. Pakistan Journal of Nutrition, Moreover, BPA can hepztoprotective the antioxidant enzymes in different body systems [ 4041 ] as noted in the current study, thus could alter normal weight gain of the experimental rats.

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Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat

Biological activity of lycopene metabolites: J Photochem Photobiol B. Carotenoids protect against cell membrane damage by the nitrogen dioxide radical.

After acclimatization for 1 wk, 65 Wistar male rats were randomized into 2 groups. The potential role of lycopene for human health.

Methods Find Exp Clin Pharmacol. Ly exhibits a range of distinct and lycopeene biological properties owing to its acyclic structure, hydrophobicity and large array of conjugated double bonds. Acetaminophen-induced acute liver failure: Lycopene LYC is an antioxidant phytochemical carotenoid. Serum Biochemical Analysis 2.